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Functional Analysis of Protein and Research Application (Focus 21) |
| FY2000-FY2005; FY2004 Project Budget: 2.19 billion yen |
A global project for the DNA sequencing of the human genome, in other words, the genetic information of human beings, has already been completed. Approximately 5 percent of the human genome contains information about proteins that play a key role in biogenic activities.
With the aim of identifying and utilizing the function of proteins, which support the biogenic activities of human beings, this project aims to develop protein function analysis technology, promote protein analysis with this technology, create a data base of biological information and develop a system for analysis, while utilizing the human full length cDNA, the human genome DNA base sequence and other information.
Development efforts focus on vectors that can effectively use human full length cDNA or splicing variant cDNA and technology for expressing large numbers of proteins. In addition, the technological development also includes collection of information about the expressivity of human genes, identification and structural analysis of interactive proteins, and analysis of protein functions using cells or model animals such as a mouse. The project also addresses the development of technology for analyzing the weak interaction of proteins and technology for protein function analysis using siRNA (small interfering RNA), which has recently become the focus of attention in this field. |
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