成果報告書詳細
管理番号20110000000924
タイトル*平成22年度中間年報「がん超早期診断・治療機器の総合研究開発/超低侵襲治療機器システムの研究開発:高精度X線治療機器の研究開発/がんの超早期局在診断に対応した高精度X線治療システム」
公開日2011/8/30
報告書年度2010 - 2010
委託先名国立大学法人北海道大学 国立大学法人京都大学 独立行政法人国立がん研究センター東病院 株式会社アキュセラ 株式会社日立製作所
プロジェクト番号P10003
部署名バイオテクノロジー・医療技術部
和文要約和文要約等以下本編抜粋:1. 研究開発の内容及び成果等 1) 小型高出力X線ビーム発生装置の開発 (1) 大電力小型加速管電子銃の開発 精度の高い計算シミュレーション方法を開発し、これを用いて、グリッドの影響の少ない球面カソードを最小化した電子銃を設計した。 また、最適化されたフェーズフォーカシング加速管の設計と部品要素の製作を実施した。これにより、ナローX線発生で最も重要である電子ビームの最適化の見通しを立てることができた。
英文要約Title:Comprehensive Research and Development of Medical Equipment for Extremely Early Detection and Treatment of Cancer / Research and Development of Super-Minimally Invasive Treatment System : Research and Development of Highly Precise X-ray Treatment Equipment / High Precision X-ray Treatment System compatible with Extremely Early Detection of Cancer (FY2010-FY2012)FY2010 Annual Report
1. A compact electron gun based on a spherical cathode with optimized grid structure has been designed utilizing newly developed high precision beam simulation technique. Moreover a phase focused accelerator has been designed, and its components were manufactured and tested.Optimizing the electron beam dynamics confirmed that the generation of narrow high energy X- ray beams is feasible.The cavity resonator, cathode, output coupling structure and the magnetic circuitry of the high power X-band coaxial magnetron have been designed and prototyped.These components have also been successfully tested for lower power level.
2. The composition of the real-time tumor tracking system equipped with the small-size high-speed FPD and the large-size FPD were determined and the functions of each component were designed.The basic design of the control sequence and the tumor tracking software were performed.The optimization of the arrangement of the hybrid-FPD tumor tracking system and the design of data transfer were started to integrate with the robotic x-ray radiation therapy system.Client servers for a motion tracking, a robot control, and an X-ray control as part of the entire control system of the robotic X ray radiation therapy system have been made.This newly developed control system has been prototyped by utilizing high-speed I/F coupling between each server and client. Moreover, the experiment was conducted for a prototype patient surveillance system using a dynamic motion stage.
3. The spec of a framework for treatment planning device was decided. Functions for reading of CT image data, image viewer, beam irradiation planning, and contouring of region of interest were developed.The system that integrated DICOM-RT server and image viewer server was constructed.The design and specification of software module for the evaluation of four-dimensional dose distribution have been determined.A data interface S/W for DICOM-RT and an image analysis S/W for measurement of respiration-induced organ motion from fluoroscopic images have been developing.A prototype system for optimizing the direction and intensity of treatment beams has been finished and the dose calculation completed. The system is based on the treatment planning data using existing RTP system. Displaying the dose distribution by overlapping the CT images has been prototyped and the DICOM-RT specification draft for the communication between the related systems finished.A Monte Carlo simulation of narrow X-ray beams has been performed and the testing environment to verify various software prototypes set up.
4. The basic design of the multiple gating system was investigated. Determination of the effective gating area in the multiple gating system has been started by analyzing the marker trajectory data stored with the real-time tumor-tracking radiotherapy system in Hokkaido University Hospital.A real time dose monitoring system for high energy X-ray treatment beams has been designed and prototyped.
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