成果報告書詳細
管理番号20110000001531
タイトル*平成22年度中間年報 「がん超早期診断・治療機器の総合研究開発/超低侵襲治療機器システムの研究開発/内視鏡下手術支援システムの研究開発」(国立大学法人九州大学)
公開日2011/11/10
報告書年度2010 - 2010
委託先名国立大学法人九州大学
プロジェクト番号P08006
部署名バイオテクノロジー・医療技術部
和文要約和文要約等以下本編抜粋:1. 研究開発の内容及び成果等
がん超早期診断・治療機器の総合研究開発/超低侵襲治療機器システムの研究開発/内視鏡下手術支援システムの研究開発について下記の研究開発を実施した。
(1) リアルタイムセンシング技術
(1)-1 センチネルリンパ節可視化及び転移検出技術
(国立大学法人信州大学、国立大学法人九州大学)
超音波造影剤ソナゾイドを用いて平成21 年度までの方法と同様に胃粘膜側から粘膜下投与を行い、ヒトでの臨床応用を実施するためにブタ腹壁上から経皮的に超音波検査を実施し、センチネルリンパ節を同定することが可能であることを確認した。さらに、リニアプローブを用いることにより、センチネルリンパ節内の辺縁洞ならびにそれに連続する類洞構造を明らかにし、リンパ節内の構造を描出して癌細胞の微小転移を診断することが可能であることを明らかにした。
英文要約Title: Research and Development Project on Surgical Support Instruments of Endoscopic Surgery (Kyushu University, The Jikei University and Shinshu University) (FY2008-FY2011) FY2010 Annual Report
1)-1 We have attempted to investigate the possible usefulness for imaging of the lymphatic channels and SLN of stomach in a porcine model using contrast-enhanced ultrasound (CEUS)-guided method with Sonazoid. The transcutaneous CEUS-guided method with Sonazoid using the contrast imagings enabled us to demonstrate clearly the imagings of the SLN of stomach. In addition, the intranodal microbubbles flowing are also able to identify clearly using the movies of tissue linear harmonic imagings of the SLN of stomach.
1)-2 It continues in the previous year, we developed novel bubble liposomes containing the ultrasound imaging gas and evaluated an ability to target.
2)-1-1 We did not execute it.
2)-1-2 We did not execute it.
2)-1-3 We have developed a prototype of an information integrated display system that can display necessary information in real-time for the operator of an endoscopic surgery system and has several kinds of navigation functions. In addition, to enable an endoscopic surgery system simulator to integrate and display the same information as the actual system, we have also developed a prototype of a system that integrates the actual system and the simulator.
2)-2 We upgraded the control software to deal with the addition of rotation and translation function to the robot arm. To deal with the addition, we also upgraded the software for the interface of the cockpit.
3)-1 As the degree of freedom of the robot arm increased, we also upgraded user interface. We also developed a function for calibration to deal with different operators.
3)-1-1 We did not execute it.
3)-3 We upgraded wire activation mechanism parts to deal with the production of a prototype with rotation and translation mechanism. We also carried out evaluation on degree of position error and degree of operational delay on the robot arm.
3)-4 We developed “all-in-one” module of the endoscopic ultrasonography and the HIFU( High-Intensity Focused Ultrasound ) transducer. And by using ultrasonographic image, We developed pursuit mechanism for HIFU target.
3)-5-1 We developed Single Port Surgical Robotic System which using the result.
3)-5-2 By using “all-in-one” module of the endoscopic ultrasonography and the HIFU, we developed a new treatment probe for Single Port Surgery.
4)-1 For beginners who are not used to using the endoscopic surgery system, we set up several tasks for training basic operations of the robot arm. We also made an evaluation system to evaluate the effects of training on the simulator such as by recording the time to complete the task and trajectory of robot arm.
4)-2 We developed a training system for a method of NOTES(Natural Orifice Transluminal Endoscopic Surgery).
5)-2 We evaluated the utility of training system for a method of NOTES.
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