成果報告書詳細
管理番号20110000001721
タイトル*平成22年度中間年報「がん超早期診断・治療機器の総合研究開発/超早期高精度診断システムの研究開発:画像診断システムの研究開発/高機能画像診断機器の研究開発(マルチモダリティ対応フレキシブルPET)」(株式会社島津製作所)
公開日2012/10/4
報告書年度2010 - 2010
委託先名株式会社島津製作所
プロジェクト番号P10003
部署名バイオテクノロジー・医療技術部
和文要約和文要約等以下本編抜粋:
1. 共同研究の内容及び成果等
1) MRI 磁場対応DOI-TOF 検出器モジュールの開発
SiPM(Silicon Photomultiplier)を用いた基礎実験を実施し、2x2 の結晶配置で検出器マップを取得した(図1)。シンチレータは2.9 mm x 2.9 mm x 26 mm のLGSO(日立化成工業製)、SiPM は受光面:6 mm x 6 mm、チャンネル数:4ch (2x2)のS10985-050C(浜松ホトニクス製)である。既存の3 次元検出器評価システムをベースとし、SiPM 用アンプや温度調整用クールインキュベータなどを追加してMRI 磁場対応DOI-TOF 検出器用の評価システムを構築した(図2)。
またMRI 環境を模擬した永久磁石、RF 送受信機、電磁気シールドで構成される磁場・RF 発生システムとスペクトラムアナライザなどの信号計測器で構成されるアナログ信号用の評価システムを構築した。
英文要約The Advanced Research and Development Project on Diagnosis and Treatment for Early Stage of Cancer / Research and Development Project on High-speck Diagnostic Equipment for Medical Imaging / Research and Development Project on Medical Imaging System / Research and Development Project on High-speck Diagnostic Equipment for Medical Imaging / Development of Flexible PET System Compatible with Multimodality Imaging

Shimadzu Corporation, FY2010 Report Abstract

1. Development of a MRI compatible DOI-TOF-PET detector module
We performed an initial test of a PET detector module consisting of 2 x 2 array of LGSO crystals (2.9 x 2.9 x 26 mm3) combined with 4-ch silicon photomultiplier (SiPM: Hamamatsu Photonics K.K., S10985-050C) and obtained 2D position histogram clearly identifying each crystal. We also built a detector data acquisition system consisting of SiPM signal amplifiers and an incubation box for maintaining temperature. In addition, we compiled analog signal measuring system and magnetic field and RF (radio frequency) generation system for evaluation of MR-compatible PET detectors. As a front-end ASIC for SiPM signal processing, we developed TEG (Test Element Group) circuits and tested them with emulated SiPM pulse signals.

2. Development of a flexible PET data acquisition system
 We have designed a flexible PET data acquisition system, which can scale up the number of data acquisition circuit boards depending on the number and the arrangement of detector modules in a flexible PET system. Simulation studies based on a data acquisition model showed that the proposed system can significantly reduce count-losses and increase both singles and coincidence count rates.

3. Development of a flexible PET data processing system
 We evaluated an image quality of a flexible PET system which consists of opposite curvature detectors (a partial ring arrangement) using image reconstruction of a simulation phantom. Results showed that time-of-flight (TOF) information can reduce artifacts and distortions of reconstructed images caused by limited-angle projections due to the partial ring arrangement.
 
4. Development of total system of a flexible PET scanner
 Using Monte-Carlo simulation, we estimated the sensitivity and count rate performance of flexible PET scanners with different partial-ring detector diameters (775 mm and 525 mm). Results showed that the flexible PET data processing system can improve noise equivalent count rate (NECR) and TOF information can increase effective sensitivities. It indicates a possibility of developing a flexible PET scanner which has higher sensitivity and NECR than conventional full-ring PET scanners.

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