成果報告書詳細
管理番号20120000000614
タイトル*平成23年度中間年報 iPS細胞等幹細胞産業応用促進基盤技術開発/ヒトiPS細胞等幹細胞を用いた創薬スクリーニングシステムの開発(
公開日2012/12/21
報告書年度2011-2011
委託先名一般社団法人バイオ産業情報化コンソーシアム 学校法人慶應義塾大学 三菱化学メディエンス株式会社 国立大学法人東京医科歯科大学
プロジェクト番号P08030
部署名バイオテクノロジー・医療技術部
和文要約和文要約等以下本編抜粋:
要旨
創薬スクリーニングシステムの開発を推進するために次の2つの課題について研究開発を推進する。
英文要約Title:Development of Safety Pharmacology Screening System by Using Stem Cells such as iPS Cells
(FY2008-FY2012)
FY2011 Annual Report
This report shows results of research and development activities of the project in the fiscal 2011 year.
This year we have changed our R&D organization and have focused on development of in vitro cardiotoxicity
detection system. The third year for the project is progressing and new facts from each research subject
are emerging.
There are several remarkable achievements in the project as follows. Stable preparation and precise characterization of stem-cell derived cardiomyocytes are the most important as research objectives.
In this year, growth and differentiation conditions have been established using human iPS cells and several differentiation factors to supply suitable amount of cells for detection system.
We successfully isolated iPS cells from hereditary QT prolongation syndrome patients type I, II and III.
Differentiated cardiomyocytes from iPS cells of the type I patients showed Torsade de pointes-like responses to IKr channel blockers in the dose-dependent manner.
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