成果報告書詳細
管理番号20120000001182
タイトル*平成23年度中間年報 「がん超早期診断・治療機器の総合研究開発/超早期高精度診断システムの研究開発:病理画像等認識技術の研究開発/病理画像等認識基礎技術の研究開発(1粒子蛍光ナノイメージングによる超高精度がん組織診断技術)」
公開日2012/12/19
報告書年度2011-2011
委託先名コニカミノルタエムジー株式会社、国立大学法人東北大学
プロジェクト番号P10003
部署名バイオテクノロジー・医療技術部
和文要約和文要約等以下本編抜粋:
[記載項目]
1. 研究開発の内容及び成果等
1超高輝度・超耐光性蛍光性ナノ粒子の研究開発
(実施体制:コニカミノルタエムジー株式会社、東北大学)
[目標]
蛍光体目標仕様を設定し、設定仕様を満たす高輝度標識剤(1 次試作)を完了する。
英文要約Comprehensive Research and Development of an Early Stage Diagnosis Method and Instruments to Treat Cancer
Research and Development of Fundamental Technology for Pathological Image Recognition (FY2010-FY2012)
Internal Repot in FY2011 
Konica Minolta Medical & Graphic, Inc. and Tohoku University
1. Research and Development of Ultra-bright and Ultra-photostable Fluorescent Nanoparticles After defining a characteristics requirement, we synthesized fluorescent nanoparticles based on the specification. By using these nanoparticles, we achieved to synthesize highly fluorescent markers. In FY2012, we will find out action items through the pathological clinical test to realize our technology and solve the issues for practical realization. In FY2013 and 2014, we will make a proposal for practical realization.
2. Research and Development of Fundamental Technology for Nano-imaging of Cancer Tissues We examined the availability of our quantitative-fluorescence measurement in a pathological diagnosis with a high-specification fluorescence microscope. The number of the samples was increased from that in FY2011. We found that the immunostaining method with fluorescent nanoparticles were quantitatively-improved in contrast to the conventional immunohistochemistry with 3,3'-diaminobenzidine. This result shows availability of our technology. To realize this concept in practical application, validation and development of this technology with low-cost microscopes will be started in the next fiscal year.
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