成果報告書詳細
管理番号20130000000173
タイトル*平成24年度中間年報「がん超早期診断・治療機器の総合研究開発 超早期高精度診断システムの研究開発 画像診断システムの研究開発 がんの性状をとらえる分子プローブ等の研究開発 」
公開日2013/11/30
報告書年度2012 - 2012
委託先名日本メジフィジックス株式会社
プロジェクト番号P10003
部署名バイオテクノロジー・医療技術部
和文要約
英文要約Title: The Advanced Research and Development Project on Diagnosis and Treatment for Early Stage of Cancer. Research and Development Project on High-speck Diagnostic Equipment for Medical Imaging. Research and Development Project on Medical Imaging System. Research and Development Project on Molecular Imaging Probes for Cancer Characterization. Molecular Imaging Probes for Cancer Characterization (FY2010-FY2012) FY2012 Annual Report
The goal of this R&D project is to develop the multi-modalities imaging methods, combining Positron Emission Tomography (PET) and other imaging devices such as MRI, for the purpose of optimizing the molecular-targeted cancer therapeutics in the personalized clinical settings. In collaboration with Kyoto University, we have decided to develop new PET imaging probes for (1) pancreatic, (2) lung, (3) breast and (4) prostate cancers. Molecular designs of these PET imaging probes would be based on pathophysiological properties and treatment strategies of each tumor. Nihon Medi-Physics (NMP) is in charge of preclinical safety evaluations of the new PET imaging probes to be developed by Kyoto University. This annual report briefly summarizes the R&D activities made by NMP for this project in fiscal year 2012. In FY2012, NMP evaluated safety studies of new pancreatic cancer imaging probes developed by Kyoto Univ. Expanded single dose toxicity studies using normal mice were performed by CRO in compliance with GLP. Test substances were administrated intravenously to male and female mice (n=10 each). General conditions and body weights of the test animals were observed for two weeks after the administration and compared with control group. After two weeks observation, the test animals were sacrificed and major organs were inspected visually. The dose of the test substances was selected among 0, 15, 30 and 60μg/kg. As a result, no adverse events caused by the test substances were confirmed following the intravenous injections of the test substances at tested doses. This means that the NOAEL of the new pancreatic cancer imaging probes is larger than 60μg/kg. Preliminary market research for the new PET imaging probes in the area of pancreatic and lung cancers were also conducted. Clinical unmet needs in these tumors as well as recent developments of molecular targeted therapeutics were reviewed from many professional congresses such as Japanese Breast Cancer Society (June 2012 in Kumamoto), World Molecular Imaging Congress (September 2012 in Dublin, Ireland). It is concluded that the understandings on molecular mechanisms of treatment-resistance such as cancer stem cells and hypoxia are critical for designing and developing new PET imaging agents.
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