成果報告書詳細
管理番号20120000001202
タイトル*平成23年度中間年報 「がん超早期診断・治療機器の総合研究開発 超早期高精度診断システムの研究開発:画像診断システムの研究開発 高機能画像診断機器の研究開発(マルチモダリティ対応フレキシブルPET」(平成23年度通常予算分)
公開日2014/6/14
報告書年度2011 - 2011
委託先名株式会社島津製作所
プロジェクト番号P10003
部署名バイオテクノロジー・医療技術部
和文要約
英文要約The Advanced Research and Development Project on Diagnosis and Treatment for Early Stage of Cancer / Research and Development Project on High-speck Diagnostic Equipment for Medical Imaging / Research and Development Project on Medical Imaging System / Research and Development Project on High-speck Diagnostic Equipment for Medical Imaging / Development of Flexible PET System Compatible with Multimodality Imaging

Shimadzu Corporation, FY2011 (ordinary budget) Report Abstract

1. Development of a MRI compatible DOI-TOF-PET detector module
We developed front-end circuit boards, including a SiPM (silicon photomultiplier) array mounting board, signal amplifier boards, and an analog processing board which generates weighed sum signals and a timing signal from output signals of a 6 x 6 SiPM array. We evaluated MRI RF (radio frequency) superposition on detector signal transfer and found that a coaxial cable with differential signaling can reduce the degradation of signal transfer performance. We also built a detector control system used for detector performance evaluation combined with the detector data acquisition system.

2. Development of a flexible PET data processing system
 Using image reconstruction with a simulated body phantom, we evaluated image qualities of flexible PET scanners with various detector positioning and cover angles of opposite curvature detectors (a partial ring arrangement). Results showed that, with an optimal detector positioning and cover angle, a flexible PET scanner with time-of-flight (TOF) information can provide better lesion detestability than a conventional full-ring PET scanner without TOF information. We implemented a backprojection of list-mode DOI-TOF reconstruction on GPU (Graphic Processor Unit) using CUDA (Compute Unified Device Architecture) and obtained a significant reduction in reconstruction time. We also developed a normalization method for dual planner detector efficiencies and evaluated it with simulation data.

3. Development of total system of a flexible PET scanner
 We designed a proof-of-concept flexible PET system consisting of opposite planner PET detectors and a small-animal MRI scanner, which enables PET/MRI imaging with rodents for evaluating image qualities. We also discussed on specifications and mechanical design of a prototype flexible PET system which enables human imaging.
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