成果報告書詳細
管理番号20120000001203
タイトル*平成23年度中間年報 「がん超早期診断・治療機器の総合研究開発 超早期高精度診断システムの研究開発:画像診断システムの研究開発 高機能画像診断機器の研究開発(マルチモダリティ対応フレキシブルPET」(平成22年度補正予算分)
公開日2014/6/14
報告書年度2011 - 2011
委託先名株式会社島津製作所
プロジェクト番号P10003
部署名バイオテクノロジー・医療技術部
和文要約
英文要約The Advanced Research and Development Project on Diagnosis and Treatment for Early Stage of Cancer / Research and Development Project on High-speck Diagnostic Equipment for Medical Imaging / Research and Development Project on Medical Imaging System / Research and Development Project on High-speck Diagnostic Equipment for Medical Imaging / Development of Flexible PET System Compatible with Multimodality Imaging

Shimadzu Corporation, FY2011 (supplementary budget of FY2010) Report Abstract

1. Development of a MRI compatible DOI-TOF-PET detector module
We developed a DOI(depth-of-interaction)-TOF(time-of-flight) PET detector module consisting of 16 x 16 array of LGSO crystals (2.9 x 2.9 x 26 mm3) combined with a 64-ch PMT (photomultiplier tube). Even with a masked light guide emulating a 6 x 6 SiPM (silicon photomultiplier) array, we obtained good energy and timing resolution with gamma ray irradiations. We also developed a PET detector module consisting of the same crystal array and a 6 x 6 SiPM and obtained a 2D position histogram clearly identifying each crystal with four-layer DOI information. As a front-end ASIC for SiPM signal processing, we developed TEG (Test Element Group) circuits and evaluated them with a PET detector consisting of a LGSO crystal and a SiPM. We obtained a short-rise-time pulse output and fed back this TEG circuit design to the total ASIC design. For evaluating effects on MRI image qualities from PET detector modules, we built a small animal MRI system and found no degradation of MRI phantom images with various PET detector parts. We also built analog signal measurement system, SiPM performance evaluation system, and production system of detector assembling jigs.

2. Development of a flexible PET data acquisition system
 We developed a flexible PET data acquisition system, which can scale up the number of data acquisition circuit boards depending on the number and the arrangement of detector modules in a flexible PET system. We also developed corresponding software of the flexible PET data acquisition system. Evaluation studies with a pair of DOI-TOF detector modules showed that the proposed system can provide good energy and timing resolution as well as 2D position histogram clearly identifying each crystal with DOI information.
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