成果報告書詳細
管理番号20130000000193
タイトル*平成24年度中間年報 「がん超早期診断・治療機器の総合研究開発 超早期高精度診断システムの研究開発:病理画像等認識技術の研究開発 病理画像等認識基礎技術の研究開発(1粒子蛍光ナノイメージングによる超高精度がん組織診断技術) 」
公開日2014/6/14
報告書年度2012 - 2012
委託先名コニカミノルタテクノロジーセンター株式会社 国立大学法人東北大学
プロジェクト番号P10003
部署名バイオテクノロジー・医療技術部
和文要約
英文要約Comprehensive Research and Development of an Early Stage Diagnosis Method and Instruments to Treat Cancer
Research and Development of Fundamental Technology for Pathological Image Recognition (FY2010-FY2012)
Internal Repot in FY2012 

Konica Minolta Technology Center, Inc. and Tohoku University

1. Research and Development of Ultra-bright and Ultra-photostable Fluorescent Nanoparticles
Staining human tissue revealed that absorption on stroma and nucleus is a problem. To suppress it, absorption of water-soluble polymer molecule on the surface of fluorescent nanoparticle was improved. As a result, the surface modification technology not to degrade non-specific absorption and antibody activity has been realized. In FY2013 and 2014, improvement as a reagent product will be explored.

2. Research and Development of Fundamental Technology for Nano-imaging of Cancer Tissues
As we were succeeded in synthesizing brighter fluorescent nanoparticle than that of last year, fluorescent spots measurement becomes available by using 20X lens rather than 40X lens (in the case of wide field scan). Improved fluorescent spots counting algorithm realizes highly accurate spots counting.
 For application to other cancers or markers, we began to apply for nucleus markers which are ER, PgR and Ki67. Modified condition for surface modification and staining makes ER and PgR staining possible. For Ki67, reduction of non-specific absorption is a problem. We will continue the improvement for the next year.
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