成果報告書詳細
管理番号20130000000253
タイトル*平成24年度中間年報 「がん超早期診断・治療機器の総合研究開発  超早期高精度診断システムの研究開発:画像診断システムの研究開発 高機能画像診断機器の研究開発(マルチモダリティ対応フレキシブルPET)」
公開日2014/6/14
報告書年度2012 - 2012
委託先名株式会社島津製作所
プロジェクト番号P10003
部署名バイオテクノロジー・医療技術部
和文要約
英文要約The Advanced Research and Development Project on Diagnosis and Treatment for Early Stage of Cancer / Research and Development Project on High-speck Diagnostic Equipment for Medical Imaging / Research and Development Project on Medical Imaging System / Research and Development Project on High-speck Diagnostic Equipment for Medical Imaging / Development of Flexible PET System Compatible with Multimodality Imaging

Shimadzu Corporation, FY2012 Report Abstract

1. Development of a MRI compatible DOI-TOF-PET detector module
We developed a four-layer DOI (depth-of-interaction) PET detector module consisting of a 16 x 16 array of LGSO crystals combined with a SiPM (silicon photomultiplier) array. The detector module was connected to the circuit boards for mounting a 6x6 SiPM array, amplifying SiPM signals in parallel and generating timing signals. We put the detector module inside a small animal MRI scanner (1.5T) and then confirmed its normal performances under MRI scanning. The intrinsic spatial resolution of 2.8 mm and the timing resolution of 576 ps were obtained with a one-pair detector system.

2. Development of a flexible PET data acquisition system
 For the dual-planner proof-of-concept (POC) PET system, we configured the flexible PET data acquisition system, which transfers the detection signals between circuit modules and judges coincidence detection. We also developed the software for generating a LUT (look-up table) of detector adjustments and acquiring detection events with the POC system. In addition, the firm software of the data acquisition system was modified to accept signals from 256 detector modules (in maximum) for developing a proto-type human PET system.

3. Development of a flexible PET data processing system
 We developed the image generation software for the dual-planner POC system. We also developed the component-based detector normalization software for the POC system and calculated normalization factors from data of a plane phantom. Furthermore, we developed a statistical image reconstruction algorithm of incomplete TOF (time-of-flight) projection data for the proto-type human PET. In addition, we accelerated the computing speed of the list-mode TOF reconstruction by GPU parallel computation.
 
4. Development of total system of a flexible PET scanner
 We developed the dual-planner POC system and installed it to Kyoto University and combined with a small-animal MRI scanner. PET and MR scans of tumor-bearing mice were performed and the tracer uptake to the tumor was visualized on the fused image of the planner PET and MR. We also designed a gantry mechanism of the proto-type human PET system, in which the detector geometric arrangement can be changed flexibly depending on the size and shape of the patient and the patient bed.
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