成果報告書詳細
管理番号20130000000426
タイトル*平成24年度中間年報 「次世代機能代替技術の研究開発 次世代再生医療技術の研究開発 有効性・安全性評価技術等の開発(生体内で自律的に成熟する臓器再生デバイスのための評価技術研究開発)」
公開日2014/6/11
報告書年度2012 - 2012
委託先名国立大学法人東京大学医学部付属病院 株式会社ツーセル 学校法人福田学園
プロジェクト番号P10004
部署名バイオテクノロジー・医療技術部
和文要約
英文要約Title: Research Project of assessment technology for Autonomous Regeneration Device (FY2010-FY2014) FY2012 Annual Report
Reconstruction of joints, based on autonomous regeneration of cartilages, would enable to promote generalization and industrialization of cartilage tissue engineering. In this project, we will establish an assessment technology to apply the autonomous regeneration for reconstruction of joints. For that purpose, we have carried out research and development described below this year. As assessment technology concerning safety of cultured cells, we continuously evaluated “LIF”, “PRG1”, and “MMP1” with MSC derived from synovium, and examined realization of these factors. Also, we found that it is possible to distinguish between MSCs and fibroblasts by measuring responses to osteocalcin and osteopontin when active vitamin D3 is added. As assessment technology concerning safety of autonomous regeneration device, we evaluated the ability of cartilage formation in the cartilage and bone defect model of pigs with μCT and X-rays. In addition, we defined levels of cartilage regeneration from grade 0 to grade 4 by histological analyses, and evaluated the formation of regenerated cartilage. As establishment of an evaluation guideline for autonomous regeneration device, we investigated the trends of performance index of the Pharmaceutical and Medical Safety Bureau in Europe, and researched the progress of clinical trials and factors influencing the progress with European specialists in this field.
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