成果報告書詳細
管理番号20140000000461
タイトル*平成25年度中間年報 がん超早期診断・治療機器の総合研究開発 超低侵襲治療機器システムの研究開発:高精度X線治療機器の研究開発 がんの超早期局在診断に対応した高精度X線治療システム
公開日2014/7/26
報告書年度2013 - 2013
委託先名国立大学法人北海道大学 国立大学法人京都大学 独立行政法人国立がん研究センター東病院 株式会社アキュセラ 株式会社日立製作所
プロジェクト番号P10003
部署名バイオテクノロジー・医療技術部
和文要約
英文要約Title:Comprehensive Research and Development of Medical Equipment for Extremely Early Detection and Treatment of Cancer / Research and Development of Super-Minimally Invasive Treatment System : Research and Development of Highly Precise X-ray Treatment Equipment / High Precision X-ray Treatment System compatible with Extremely Early Detection of Cancer (FY2010-FY2013)FY2013 Annual Report

1、 A linear accelerator has been manufactured in 2013 and beam stability has been confirmed by simulation. Good symmetry of the X-ray beam has been obtained by adjusting the steering coil mounted to the accelerator. We optimized the coaxial cavity, the cathode position and the position of the higher order mode absorber of the high power magnetron prototype. As a result the magnetron delivers a stable RF peak power of 1.97 MW with a duty cycle of 0.001.We improved the opening mechanism of the slot shaped, continuously variable collimator and confirmed repeated opening with an accuracy of around 0.1mm or less. The rise of the internal temperature has been prevented by installing a cover and cooling the inner X-ray head.
2) Communication function with a treatment console and a DICOM server was validated. A dynamic phantom for safety control of the 4DRT system was developed. Software of fluoroscopic-DRR fusion was developed for patient setup. (1)The maintenance and scalability of the interlock system has been improved. A function for daily checking and pre-verification was added to the console of the radiation therapy safety device. The console supports suspending and resuming treatment in order to follow a treatment plan.
3) Plug-in functions of the GPU-based 3D view, the auto-definition of ROI on multi-phase CT image were developed on the framework for the RTP system by feeding back opinion of many medical physicists and radiation oncologists. The developed software for 4D dose calculation was validated using clinical 4D-CT data. It has achieved acceptable accuracy for clinical use in the thoracic region. The 4D dose calculation program was compiled into a library to integrate with the framework. We have improved the operation of the treatment planning system to allow a user to follow a unified treatment plan. We also implemented Monte Carlo dose calculation and a optimization technique to better concentrate the dose onto the boundary of the PTV. We summarized the evaluation of usability, including the performance and clinical use of the integrated version of the entire treatment plan.
4) Integrated plan and phase plans for multi-phase gating were loaded correctly to the software via DICOM communication. RTRT data transfer with the radiation treatment plan verifying system was tested. We now observe the 250PPS high-speed detection system and the linearity and symmetricity of the X-ray beam by a visible ray camera. Real-time treatment verification function of the radiation treatment plan verifying system was tested with the console of the robotic linac.
5) We studied technical standards and started data acquisition to comply with application procedures for FDA and PMDA approval. We therefore developed a device for measuring X-rays.
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