成果報告書詳細
管理番号20140000000399
タイトル*平成25年度中間年報 「次世代機能代替技術の研究開発 次世代再生医療技術の研究開発 少量の細胞により生体内で自己組織の再生を促す自律成熟型再生デバイスの開発(生体内で自律的に成熟する臓器再生デバイスのための実用化研究開発)」
公開日2014/8/20
報告書年度2013 - 2013
委託先名株式会社スリー・ディー・マトリックス 野村ユニソン株式会社
プロジェクト番号P10004
部署名バイオテクノロジー・医療技術部
和文要約
英文要約Title: Industrialization Research Project for Autonomous Regeneration Device (FY2010-FY2014) FY2013 Annual Report

Reconstruction of joints, based on autonomous regeneration of cartilages, would enable to promote generalization and industrialization of cartilage tissue engineering. In this project, we will establish an industrialization technology to apply the autonomous regeneration for reconstruction of joints. For that purpose, we have carried out research and development described below, this year. As industrialization of a hydrogel as a scaffold to realize autonomousc regeneration, semicommercial scale production of a self-assembling peptide “PRG” has been achieved. Optimum composition of PRG, PuraMatrix, PEG, Chitosan mixture was determined. We investigated excellent gelling properties and cell proliferations in vivo, which realize the concept of self-regeneration medicine of cartilage from smaller number of cells. As industrialization of a culture module for construction of autonomic regeneration, we carried out an improvement examination in consideration of problems in the production of the cell culture module which occur when a hollow fiber is used with β-TCP. We examined the fixation method with which a hollow fiber could be cut easily after cell culture and carried out the production of the examination module.
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