成果報告書詳細
管理番号20140000000503
タイトル*平成25年度中間年報 「がん超早期診断・治療機器の総合研究開発 超早期高精度診断システムの研究開発:画像診断システムの研究開発  高機能画像診断機器の研究開発(マルチモダリティ対応フレキシブルPET) 」
公開日2015/3/20
報告書年度2013 - 2013
委託先名株式会社島津製作所
プロジェクト番号P10003
部署名バイオテクノロジー・医療技術部
和文要約
英文要約The Advanced Research and Development Project on Diagnosis and Treatment for Early Stage of Cancer / Research and Development Project on High-speck Diagnostic Equipment for Medical Imaging / Research and Development Project on Medical Imaging System / Research and Development Project on High-speck Diagnostic Equipment for Medical Imaging / Development of Flexible PET System Compatible with Multimodality Imaging

Shimadzu Corporation, FY2012 Report Abstract

1. Development of an MRI compatible DOI-TOF-PET detector module
For the prototype human system of Flexible PET, we newly developed a four-layer DOI (depth-of-interaction) PET detector module consisting of four sub-block of a 8 x 8 array of LGSO crystals combined with four light guides. The detector module was connected to the front-end circuit boards, which mount a 4 x 4 4ch SiPM (silicon photomultiplier) array, ASICs for amplifying SiPM signals and generating timing, positioning and energy signals. We evaluated the detector module and then obtained a coincidence timing resolution of 487 ps.

2. Development of a flexible PET data acquisition system
 In order to reduce the cost and RF emitting noise for the prototype human system, we redesigned the flexible PET data acquisition system which transfers the detection signals between circuit modules and judges coincidence detection. We also developed the data acquisition software for adopting the new detector modules and the new data acquisition boards.

3. Development of a flexible PET data processing system
 We developed the component-based detector normalization software for the prototype human system and calculated normalization factors for various detector head configurations. For reducing the noise and artifacts generated from incomplete TOF (time-of-flight) projection data, we improved the statistical image reconstruction algorithm and evaluated the image quality with simulation for the prototype human system.
 
4. Development of total system of a flexible PET scanner
 We developed the mechanical gantry for the prototype human system in which the detector geometric arrangement can be changed flexibly depending on the size and shape of the patient and the patient bed. We also designed a detector head mechanism, including detector units and cooling systems.
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