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成果報告書詳細
管理番号20170000000707
タイトル*平成28年度中間年報 次世代人工知能・ロボット中核技術開発 (革新的ロボット要素技術分野)生体分子ロボット 分子人工筋肉の研究開発
公開日2017/8/16
報告書年度2016 - 2016
委託先名国立大学法人東京工業大学 国立大学法人北海道大学 国立大学法人北陸先端科学技術大学院大学
プロジェクト番号P15009
部署名ロボット・AI部
和文要約
英文要約Strategic Advancement of Multi-Purpose Ultra-Human Robot and Artificial Intelligence Technologies, Future Robot Technology, Molecular Artificial Muscle Project (FY2016 - FY2017), FY2016 Annual Report

In 2016 fiscal year, the Hokkaido University-Kansai University team, the JAIST-Oosaka University team and the TITECH-AIST team achieved the following researches with regards to artificial sarcomere unit, artificial muscle construction system and supramolecular design and simulation system, respectively.

(1) Artificial sarcomere unit (the Hokkaido University and Kansai University team)

The objectives of this study are creation of artificial sarcomere unit, development of artificial sarcomere unit relaxation mechanism, and acceleration of artificial sarcomere unit development. The achievements in 2016 fiscal year are the following.

As for the artificial sarcomere unit, we designed four kinds of rod shaped origami structures which could be used for the axis of kinesin rods, one of key components of the artificial sarcomere unit. We also designed the adapter DNA origamis winding on the terminal of DNA-modified microtubules. All the DNA origami structures are observed with atomic force microscope (AFM).

As for the artificial sarcomere unit relaxation mechanism, we developed DNA modified kinesins and DNA modified miroctubules. The DNA modified kinesins retain more than 90 percent kinesin activities, much higher than the original expectation of 25 percent. According to the sliding microtubules observation under a fluorescence microscope, the velocity of DNA modified microtubules is not considerably affected (less than 50%), that might be enough to realize the functioning of artificial sarcomere.

In order to accelerate the development of artificial sarcomere units, we developed the production system of kinesin and microtubule parts and set up the light control system for artificial sarcomere unit in both Hokkaido University and Kansai University. In addition to this, we also set up a production system of modified microtubules with reversible photoresponsive DNA strands in order to develop the light control system of artificial sarcomere unit.

(2) Artificial muscle construction system (the JAIST and Oosaka University team)

The objectives of this study are the developments of mechanical system of artificial muscles, an artificial muscle construction/evaluation system, and a prototype micro manipulator. The achievements in 2016 fiscal year are the following. As for the mechanical system of artificial muscle, we investigated molecular mechanism of artificial muscle formation. As the result, we found that c-terminal region of kinesin inhibits the contraction of artificial muscle. By removing this region using genetic engineering, the speed of contraction was remarkably improved.
As for the construction/evaluation system of artificial muscle, a manufacturing system of micro mechanical systems with such artificial muscles and a force measurement system for evaluation of performance of artificial muscles are proposed based on artificial muscles formed by the self-assembly of molecular motors. The system was designed to mass-produce micro mechanical systems utilizing stereo-lithography combined with microfluidics technology and high precision force sensor. As for the micro manipulator prototype, we performed the preliminary experiment for developing a prototype of micro manipulator driven by artificial muscle. We developed a tubular structure with a diameter of one millimeter, which is comparable in size to the micro manipulator and has a flexible film of parylene. We succeeded in the formation of artificial muscle in the micro tube.
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