成果報告書詳細
管理番号100013758
タイトル*平成20年度中間年報 化合物等を活用した生物システム制御基盤技術開発(H18-H21)
公開日2009/4/24
報告書年度2008 - 2008
委託先名社団法人バイオ産業情報化コンソーシアム
プロジェクト番号P06008
部署名バイオテクノロジー・医療技術開発部
和文要約以下本編抜粋:本プロジェクトは、ポストゲノム研究の産業利用が期待される「ゲノム創薬」の加速を支援することを目的とし、我が国の強みとする完全長cDNAリソース及び、世界最高レベルのタンパク質の相互作用解析技術等を最大限に活用し、創薬ターゲット候補となりうるタンパク質相互作用の解析等により創薬ターゲット候補の絞り込みを行うとともに、疾患等の生物現象を制御する新規骨格化合物等の探索・評価を行うための技術開発を行っている。
英文要約Title: Development of basic technologies for the biological system control by using chemical compounds. (FY2006-FY2009) FY2008 Annual Report In order to support the acceleration of "genome-based drug discovery" which is an expected industrial application of post-genome research, the project will identify possible target candidates for new medicines and analyze the disease mechanisms by using the protein-protein interaction information. The research is using the human full length cDNA clones which are a technical strength of Japan and the world-leading technology to analyze protein interactions by the mass spectrometry system. And the project will also develop a technology for screening and evaluating chemical compounds that control biological function relating to disease. The major research subjects and the results are as follows; (1)Development of the protein network analysis technology More than 1,800 protein-protein interaction information relating to disease were newly obtained, by the full-automated mass spectrometry system of highly precise protein network analysis. Consequently, 120 candidate interactions for drug target were acquired. (2) Development of the disease-related gene finding technology 231 target interacting proteins of diabetes were identified, by protein interaction analysis of 18 candidate genes which were obtained by previous works in this project. In the knock-in chimera mice system, newly 22 genes were analysed. Moreover, 2 patents were applied for cancer treatment, based on studies of 6 candidate genes which were obtained by previous works. (3)Development of the screening technology for chemical compounds The natural product library of the world maximum size (more than 250,000 samples) was constructed. Using this library, more than 10 screening were performed, consequently 27 new bioactive compounds were obtained. (4)Development of the chemical technology for high performance compounds The unique block synthetic method of telomestatin was established. Using this method, highly active inhibitors of telomerase were obtained.
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