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成果報告書詳細
管理番号20190000000248
タイトル*2018年度中間年報 次世代人工知能・ロボット中核技術開発 (革新的ロボット要素技術分野)生体分子ロボット 分子人工筋肉の研究開発
公開日2019/6/19
報告書年度2018 - 2018
委託先名国立大学法人東京工業大学 国立大学法人北海道大学 国立大学法人北陸先端科学技術大学院大学
プロジェクト番号P15009
部署名ロボット・AI部
和文要約
英文要約Title: Strategic Advancement of Multi-Purpose Ultra-Human Robot and Artificial Intelligence Technologies, Future Robot Technology, Molecular Artificial Muscle Project (FY2016 - FY2019), FY2018 Annual Report

In 2018 fiscal year, the Hokkaido University-Kansai University team, the JAIST-Oosaka University team and the TITECH-AIST team achieved the following researches with regards to artificial sarcomere unit, artificial muscle construction system and supramolecular design and simulation system, respectively.

(1) Development of photoresponsive artificial sarcomere (Hokkaido University, Kansai University Team)

The objective of this study is development of artificial sarcomere that responds to photo signal. The achievements in 2018 fiscal year are the following.

Kansai University group has revised and improved the design of adaptor DNA origami unit and confirmed the structure by atomic force microscope. Photoresponsive linker DNA strand was also designed and synthesized. Hokkaido University group has combined DNA modified microtubules and adaptor DNA origami unit provided by Kansai University, and established smooth muscle model system that dynamically contract in the presence of ATP.

(2) Development of prototype of micromechanical system using artificial sarcomere unit (JAIST and Osaka University team)

The objectives of this study are the improvement of the contraction force of the artificial muscle and purification method of motor protein. The achievements in 2018 financial year are the following.
JAIST group has investigated the properties of the artificial muscle in detail and improved the contraction force by optimizing the contraction conditions. The yield of motor protein increased about four times by improving the cultivation method of cell using the fermenter. Osaka University group has developed 3D printing systems of the artificial muscle. These systems consists of UV laser with 2D galvano mirror and DMD, and microfluidic control system. Using these systems, the total processing time and speed has improved.

(3) Supramolecular design and simulation system (Tokyo Institute of Technology, Advanced Institute of Science and Technology Team)

The objectives of this study are development of real-time simulation system, super molecule design user interface and discovery of tubulin stabilizers with less toxicity compared to taxol. The achievements in 2018 fiscal year are the following.

As for the real-time simulation system, we achieved molecular dynamic simulation with more than 16 million atoms including DNA-origami, Mica film and water molecules, followed by the visualization by means of virtual reality simulation running on multiple GPUs. The method realizes intuitive interface to handle super molecules such as DNA origami and microtubules.

We performed molecular modeling study based on the reported complex structures of tubulin polymer and dimers to investigate binding mode of template tubulin-stabilizers for tagging tubulin polymer. We obtained a binding mode of a known triazolopyrimidine derivative that oriented towards the inside of the cylinder of tubulin polymer. Conversely, we found that Colchicine and Combretastatin occupied a deep binding site in the wall of the cylinder of tubulin polymer.
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